2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Hippo (MST)

Hippo (MST) 

Hippo signaling pathway, also known as the Salvador/Warts/Hippo (SWH) pathway, controls organ size in animals through the regulation of cell proliferationand apoptosis. The Hippo pathway consists of a core kinase cascade in which Hpo phosphorylates the protein kinase Warts (Wts) Hpo (MST1/2 in mammals) is a member of the Ste-20 family of protein kinases. This highly conserved group of serine/threonine kinases regulates several cellular processes, including cell proliferation, apoptosis, and various stress responses.

Hippo (MST) 相关产品 (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100526
    XMU-MP-1 Inhibitor 99.51%
    XMU-MP-1是可逆和选择性的 MST1/2 抑制剂，IC50 分别为71.1和38.1 nM。
    XMU-MP-1
  • HY-128206
    I3MT-3 Inhibitor 99.98%
    I3MT-3 (HMPSNE) 是有效、选择性和具有细胞膜渗透性的 3-巯基丙酮酸硫转移酶 (3MST) (IC50=2.7 μM) 的抑制剂，对其他硫化氢/磺胺制硫酶没有活性。I3MT-3 靶向位于 3MST 活性位点的过硫半胱氨酸残基。
    I3MT-3
  • HY-101275
    EMT inhibitor-1 Inhibitor 99.53%
    EMT inhibitor-1 是 Hippo，TGF-β 和 Wnt 信号通路的抑制剂，并拥有抗肿瘤活性。
    EMT inhibitor-1
  • HY-151257
    IHMT-MST1-58 Inhibitor 99.05%
    IHMT-MST1-58 是一种有效的、选择性的 STE20-like protein 1 kinase (MST1) 抑制剂，具有口服活性，IC50 值为 23 nM。IHMT-MST1-58 可用于 1 型或 2 型糖尿病的研究。
    IHMT-MST1-58
  • HY-157932
    MR24 Inhibitor
    MR24 是一种 G-5555 (HY-19635) 衍生物，是一种哺乳动物 STE20 样 (MST)激酶抑制剂。MR24 选择性靶向 MST3/4，EC50 值分别为 57 和 583 nM。
    MR24
  • HY-160211
    JA310 Inhibitor
    JA310 是一种高选择性的 MST3 激酶抑制剂。JA310 对 MST3 具有高细胞效力，EC50 值为 106 nM。
    JA310
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